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National Institute of Pharmaceutical Education and Research (NIPER) - Ahmedabad

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Dr.Hemant Kumar

Dr. Hemant Kumar, PDF, Ph.D.

Assistant Professor

Research Interest

  • The death of the endothelial cell continues throughout the acute phase of the spinal cord injury (SCI), predominantly at the injury epicenter.
  • My major research area is to find the target or NCEs for endothelial protection/stabilization within penumbral microvasculature and preserving the blood-spinal cord barrier integrity.
  • Additionally, I am also evaluated the effect of biomaterials/nanoparticles on injured spinal cord.
  • Additionally, I have vast experience in animal model development in diverse therapeutic areas, including spinal cord injury, Parkinson’s disease, neuropathic &inflammatory pain, multiple sclerosis, and arthritis.

Experience

  • January 2020 -Present
    Assistant Professor

    NIPER- Ahmedabad, Palaj, Gandhinagar

  • September 2017 – January 2020
    Assistant Professor

    CHA University South Korea

  • December 2015 – August 2017
    Korean Research Fellow

    CHA University, South Korea

  • December 2009 – February 2011
    Senior Research Biologist

    Chembiotek (TCG Lifescience),Kolkata

  • April 2009 – December 2009
    Research officer

    Glenmark Pharmaceuticals,Mumbai

  • May 2007 – March 2009
    Research Associate

    Glenmark Pharmaceuticals, Mumbai

  • June 2006 – March 2007
    Research Trainee

    CDRI,Lucknow

Honours

  • Brain Korea-21 (BK-21) scholarship for doing Ph.D
  • BK-21 award for the year 2012-2013 and 2013-2014 (Highest impact factor).
  • Full scholarship assistance for doing Master’s by Government of India (GATE).
  • Korea Research Fellowship (KRF) for doing Postdoc.
  • Best Oral presentation award in Biospine Asia Pacific 2018 held at Yonsei University April 27, 2018.
  • Wiltse Academic Award at the 32nd Annual meeting of the Korean Spinal Neurosurgery Society September 14, 2018.

Publications

  • Songhyun Lim, Seong Bae An, Mungyo Jung, Hari Prasad Joshi,
    Hemant Kumar    , Cheesue Kim, Seuk Young Song, Ju-Ro Lee, Mikyung Kang, Inbo Han, Byung-Soo Kim. (2021). Local Delivery of Senolytic Drug Inhibits Intervertebral Disc Degeneration and Restores Intervertebral Disc Structure, Advanced Healthcare Materials.
    2101483. https://doi.org/10.1002/adhm.202101483
  • Kirti Adhikari, Sonam Dolma, Teena Mamidi, Abhishek Roy, Zarna Pathak, and
    Hemant Kumar    . (2021). Tomographic Imaging and Correlation to Quantify Vascular and Inflammatory Changes in an Experimental Spinal Cord Injury, ACS Chemical Neuroscience. org/10.1021/acschemneuro.1c00390
  • Mounika Choppadandi, Aditya Teja Guduru , Piyush Gondaliya , Neha Arya, Kiran Kalia,Hemant Kumar, Govinda Kapusetti. (2021). Structural Features Regulated Photoluminescence Intensity and Cell Internalization of Carbon
    and Graphene Quantum Dots for Bioimaging, Materials Science and Engineering: C. 112366. doi.org/10.1016/j.msec.2021.112366
  • Abhishek Roy, Zarna Pathak, Hemant Kumar. (2021). Strategies to neutralize RhoA/ROCK pathway after spinal cord injury, Experimental Neurology. 343, doi.org/10.1016/j.expneurol.2021.113794
  • Sonam Dolma & Hemant Kumar. (2021). Neutrophil, Extracellular Matrix Components, and Their Interlinked Action in Promoting Secondary Pathogenesis After Spinal Cord Injury, Molecular Neurobiology. doi.org/10.1007/s12035-021-02443-5
  • Kumar H, Lim CS, Choi H, Joshi HP, Kim K-T, Kim YH, et al. Elevated TRPV4 levels contribute to endothelial damage and scarring in experimental spinal cord injury. Journal of Neuroscience. 2020. 40 (9) 1943-1955, (I.F-
    6.07)
  • Kumar H, Choi H, Jo M-J, Joshi HP, Muttigi M, Bonanomi D, et al. Neutrophil elastase inhibition effectively rescued angiopoietin-1 decrease and inhibits glial scar after spinal cord injury. Acta neuropathologica communications.
    2018;6(1):1-18. (I.F- 5.88)
  • Kumar H, Lee S-H, Kim K-T, Zeng X, Han I. TRPV4: a sensor for homeostasis and pathological events in the CNS. Molecular neurobiology. 2018;55(11):8695-708. (I.F- 4.58)
  • Kim HY$,Kumar H, Jo M-J, Kim J, Yoon J-K, Lee J-R, et al. Therapeutic efficacy-potentiated and diseased organ-targeting nanovesicles derived from mesenchymal stem cells for spinal cord injury treatment. Nano letters.
    2018;18(8):4965-75. (Co-first) (I.F- 12.27)
  • Kumar H, Ha D-H, Lee E-J, Park JH, Shim JH, Ahn T-K, et al. Safety and tolerability of intradiscal implantation of combined autologous adipose-derived mesenchymal stem cells and hyaluronic acid in patients with chronic
    discogenic low back pain: 1-year follow-up of a phase I study. Stem cell research & therapy. 2017;8(1):262. (I.F- 4.62)
  • Kim HJ, Lim CS, Lee HW, Lee HS, Um YJ, Kumar H, et al. A ratiometric two-photon probe for Ca2+ in live tissues and its application to spinal cord injury model. Biomaterials. 2017;141:251-9. (I.F-10.27)
  • Kumar H, Jo M-J, Choi H, Muttigi MS, Shon S, Kim B-J, et al. Matrix Metalloproteinase-8 Inhibition Prevents Disruption of Blood–Spinal Cord Barrier and Attenuates Inflammation in Rat Model of Spinal Cord Injury. Molecular
    neurobiology. 2018;55(3):2577-90. (I.F- 4.58)
  • Ahn J$,Kumar H,Cha BH, Park S, Arai Y, Han I, et al. AIMP1 downregulation restores chondrogenic characteristics of dedifferentiated/degenerated chondrocytes by enhancing TGF-β signal. Cell death & disease. 2017;7(2):e2099.
    (Co-first) (I.F- 5.95)
  • Kumar H, Kim I-S, More SV, Kim B-W, Choi D-K. Natural product-derived pharmacological modulators of Nrf2/ARE pathway for chronic diseases. Natural product reports. 2014;31(1):109-39. (I.F- 11.87)
  • Kumar H,Choi D-K. Hypoxia inducible factor pathway and physiological adaptation: a cell survival pathway? Mediators of inflammation. 2015;2015. (I.F- 3.54)
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